Replacement of 8-MOP/UV-A treatment by UV-C irradiation for further development of Extracorporeal Photopheresis
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15 صفحه اولIn vitro effects of different 8-methoxypsoralen treatment protocols for extracorporeal photopheresis on mononuclear cells
Extracorporeal photopheresis (ECP) is an important second-line therapy for graft-versus-host disease. A central therapeutic mechanism is the induction of immune tolerance through apoptosis in patient's leukocytes, caused by ex vivo incubation with 8-methoxypsoralen (8-MOP) and subsequent UVA irradiation. We hypothesized that different 8-MOP incubation times and an additional 8-MOP removal step ...
متن کامل[Extracorporeal photopheresis in dermatology].
Extracorporeal photochemotherapy or photopheresis is an immunomodulatory therapy that combines leukapheresis with phototherapy. Blood from the patient is processed to give a leukocyte-rich plasma, which is then treated ex vivo with a photosensitizer and ultraviolet A radiation before reinfusion back into the patient. The exact mechanism of action of photopheresis has not been fully elucidated a...
متن کاملClinical Results of Extracorporeal Photopheresis.
Extracorporeal photopheresis (ECP) is a combination of leukapheresis and photodynamic therapy in which blood is treated with photoactivable drugs which are then activated with ultraviolet light and re-infused to the patient. It has been used successfully for more than 30 years in the treatment of erythrodermic cutaneous T-cell lymphoma (CTCL) and over 20 years for chronic graft-versus-host dise...
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ژورنال
عنوان ژورنال: Hematology and Medical Oncology
سال: 2021
ISSN: 2398-8495
DOI: 10.15761/hmo.1000221